Molecular monitoring of wastewater to help Public Health understand the presence of disease in a community and inform intervention strategies
+ regardless of clinical testing strategies, access to testing, and the sample size of symptomatic individuals who have taken tests 
- methods (and labs) remain disparate
- QAQC measures (?)
Quis custodiet ipsos custodes?
so with the interlabs the past four years, we’re at the stage where none of the methods are wild anymore (though sitll good to keep an eye on mutation effects) - so we can evolve to a high level task (which is our mandate for PHAC)
R <- anywhere from 10-20 labs. each with their own established spreadsheets filling the unified interlab submittal. granularly for statistical tests - three replicates of three replicates of however many targets (we provide for 4 different SARS genes, flu A, flu B, the 3 RSVs) which are different for each lab
| Interlab | Proficiency Test | |
|---|---|---|
| Principle | Methods comparison, research | Quality management (ISO 17431) |
| Performance Threshold | z score>3 | z score>3 |
| QAQC Threshold | Terms of Reference check-list | Terms of Reference check-list |
| Participants | Ontario labs (13) | non-Ontario, U.S. labs (& Ontario opt-in’s) |
| Consulting service (diagnostics) | Yes | No |
| Deliverables | Report with performance, QAQC review, debrief, conformance report to Ministry | Report with performance, QAQC review, h-k plots |
| Eligible for certification | No | Yes, e.g. CALA |
- develop the visibility for quality control
- client/lab-side quality check for PT (web dev….)
- code refactoring & continue documentation
Contact: jho@ocwa.com || @githubjjyh
